Abstract: This presentation will address the frameworks, principles and standards constructs that can be applied to STEM education for hands-on, inquiry, and project-based learning to meet the goal of preparing students for pursuing STEM related fields in college and careers. Teacher preparation in content, pedagogy and technology helps teachers to be able to help their students reach their goals This presentation will provide an overview of Next Generation Science standards designed to reform curriculum and may encourage study and careers in STEM. The TPACK framework will be presented as a guide for integrating technology in content and pedagogy. The principles and guidelines for Universal Design for Learning provide more specific direction for features of technology and instructional materials so that all students have the opportunity to participate and make progress in the general education curriculum and instruction.