Abstract: TPACK framework brings a new approach to help teachers incorporate technologies into their classes. However, it is still not clear how science teachers could be assisted to master critical TPACK. In this paper, based on the relevant literature, we propose several principles to design and develop science teachers’ TPACK curriculum. We will illustrate how we use these principles in a Race to the Top (RT3) online self-paced professional development course. Those principles demonstrate our effort to advance related knowledge. Discussion of these principles would have implications for other similar course design or professional development program.